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Eukaryotic Transcription Factors, Fifth Edition

2012-02-16 
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Eukaryotic Transcription Factors, Fifth Edition 去商家看看

 Eukaryotic Transcription Factors, Fifth Edition


基本信息·出版社:Academic Press
·页码:488 页
·出版日期:2007年10月
·ISBN:0123739837
·条形码:9780123739834
·装帧:平装
·正文语种:英语

内容简介 在线阅读本书

Transcription, or the process by which DNA produces RNA, is a central aspect of gene expression. Transcription factors regulate transcription during development and in disease states. As such, it is critical for researchers to gain a good understanding of the relationship between the structure of various families of transcription factors and their function, as well as roles in human disease. Since publication of the Fourth Edition, there have been major advances, notably in the areas of chromatin remodeling and genome-scale analyses. This complete update includes all new coverage of the latest developments, from enabling genomic technologies to studies on the importance of post-translational modifications beyond phosphorylation events.

Brand new coverage in this edition includes:
* Potential of transcription factors as therapeutic targets in human disease
* Importance of histone modifications
* Use of genome-based sequence analysis and high-throughput methods
* Applications of the chromatin immunoprecipitation (ChIP) assay
* Transcriptional elongation
* Regulation by post-translational modifications
* Regulatory networks and bioinformatics
作者简介 Dr. Goodman has forty-five years of experience teaching endocrinology and physiology to medical students at Harvard Medical School and at the University of Massachusetts Medical School. He has been engaged in NIH funded research in endocrinology for 40 years and published more than 150 articles in leading endocrinology journals. He is the founding Chairman of his department at UMass and has recently retired as Chairman after serving for 36 years..


编辑推荐 Review
Praise for the previous edition:
.,."clear chapter organization and elegant illustration. It would be a useful purchase for academic and clinical medical libraries, and may be picked up as the primary text for courses in endocrinology at medical schools."
-E-STREAMS (2003)
.,."provides first year medical students with a basic knowledge of normal endocrine physiology a both cellular and molecular levels and prepare them for more advanced studies of endocrine pathology and therapies."
-TRENDS IN ENDOCRINOLOGY & METABOLISM (September 2003)
.,."provides a solid overview of endocrine function and control...an introductory text that provides a solid basis of background information for the aspiring clinician, or for students planning to progress in a direction that investigates a broader range of organisms."
- GENERAL & COMPARATIVE ENDOCRINOLOGY (July 2003)
.,."presents the subject of human endocrinology in a way that actually makes the reader want more...this is an outstanding text for medical students, graduate students, and researchers who need a good reference book in the field."
-LIFE SCIENCE BOOK REVIEW (2003)
"Basic Medical Endocrinology should provide first year medical students with a basic knowledge of normal endocrine physiology at both cellular and molecular levels and prepare them for more advanced studies of endocrine pathology and therapies."
-UNIVERSITY OF NEW MEXICO HEALTH SCIENCES CENTER
"The fourth edition of this highly successful textbook continues to have the same focus as previous editions-the integrative and regulatory roles of the endocrine systems, with up-to-date coverage of important advances in cellular and molecularmechanisms. The integrative focus of this book reflects the over 40 years of experience of the editor with teaching physiology and endocrinology to medical students. It is precisely the integrative focus that makes this textbook so valuable. The first chapters provide an overview of the principles of hormone structure and function and the roles of the primary endocrine glands. The remaining chapters deal with how hormones serve to regulate complex physiological functions, such as fuel metabolism, regulation of salt and water balance, calcium balance, growth and reproduction. These chapters provide an integrative framework for understanding how these functions respond to challenges from the internal or external environment.
Immediately noticeable in the fourth edition is the rich look of the book with its new color figures (300 total) that make many of the illustrations easier to understand. This book continues to be very readable, concise and provides sufficient basic knowledge of how a particular system works without getting bogged down in the unmanageable details of intracellular signaling cascades or regulation of gene transcription. It provides the framework on which a student can add more complex detail of a specific cell or tissue or of a hormone-related disease. An important change in this book is the increase in coverage of the regulation of fuel metabolism, which is covered in 3 chapters: Hormones of the GI Tract (completely new chapter), The Pancreatic Islets, and Hormonal Regulation of Fuel Metabolism. This increase in coverage is appropriate and reflects the very strong emphasis on this area of research over the past 10 years. The increase in obesity and diabetes in ourpopulation has provided the stimulus for this research, which has led to a sizable growth in knowledge of this very complex area. Revisions of other chapters capture most new advances, without greatly expanding the length of the text. However, managing this feat requires leaving out some information. For example, there is no mention of the discovery of kisspeptin, which is made in neurons in the hypothalamus. Kisspeptin is now considered to be the primary regulator of GnRH neurons and reproductive function. Also, it is likely that a future edition will consider adipose tissue as an endocrine organ, reflecting the array of hormones synthesized by adipocytes and its importance in glucose homeostasis and the metabolic syndrome.
Overall, the textbook is essential for medical students. It also can serve as a valuable resource for an upper level undergraduate course or a first year graduate course."
-Endocrine, December 2008

Review
Praise for the previous edition:

"...clear chapter organization and elegant illustration. It would be a useful purchase for academic and clinical medical libraries, and may be picked up as the primary text for courses in endocrinology at medical schools."
-E-STREAMS (2003)

"...provides first year medical students with a basic knowledge of normal endocrine physiology a both cellular and molecular levels and prepare them for more advanced studies of endocrine pathology and therapies."
-TRENDS IN ENDOCRINOLOGY & METABOLISM (September 2003)

"...provides a solid overview of endocrine function and control...an introductory text that provides a solid basis of background information for the aspiring clinician, or for students planning to progress in a direction that investigates a broader range of organisms."
- GENERAL & COMPARATIVE ENDOCRINOLOGY (July 2003)

"...presents the subject of human endocrinology in a way that actually makes the reader want more...this is an outstanding text for medical students, graduate students, and researchers who need a good reference book in the field."
-LIFE SCIENCE BOOK REVIEW (2003)

"Basic Medical Endocrinology should provide first year medical students with a basic knowledge of normal endocrine physiology at both cellular and molecular levels and prepare them for more advanced studies of endocrine pathology and therapies."
-UNIVERSITY OF NEW MEXICO HEALTH SCIENCES CENTER

"The fourth edition of this highly successful textbook continues to have the same focus as previous editions-the integrative and regulatory roles of the endocrine systems, with up-to-date coverage of important advances in cellular and molecular mechanisms. The integrative focus of this book reflects the over 40 years of experience of the editor with teaching physiology and endocrinology to medical students. It is precisely the integrative focus that makes this textbook so valuable. The first chapters provide an overview of the principles of hormone structure and function and the roles of the primary endocrine glands. The remaining chapters deal with how hormones serve to regulate complex physiological functions, such as fuel metabolism, regulation of salt and water balance, calcium balance, growth and reproduction. These chapters provide an integrative framework for understanding how these functions respond to challenges from the internal or external environment.

Immediately noticeable in the fourth edition is the rich look of the book with its new color figures (300 total) that make many of the illustrations easier to understand. This book continues to be very readable, concise and provides sufficient basic knowledge of how a particular system works without getting bogged down in the unmanageable details of intracellular signaling cascades or regulation of gene transcription. It provides the framework on which a student can add more complex detail of a specific cell or tissue or of a hormone-related disease. An important change in this book is the increase in coverage of the regulation of fuel metabolism, which is covered in 3 chapters: Hormones of the GI Tract (completely new chapter), The Pancreatic Islets, and Hormonal Regulation of Fuel Metabolism. This increase in coverage is appropriate and reflects the very strong emphasis on this area of research over the past 10 years. The increase in obesity and diabetes in our population has provided the stimulus for this research, which has led to a sizable growth in knowledge of this very complex area. Revisions of other chapters capture most new advances, without greatly expanding the length of the text. However, managing this feat requires leaving out some information. For example, there is no mention of the discovery of kisspeptin, which is made in neurons in the hypothalamus. Kisspeptin is now considered to be the primary regulator of GnRH neurons and reproductive function. Also, it is likely that a future edition will consider adipose tissue as an endocrine organ, reflecting the array of hormones synthesized by adipocytes and its importance in glucose homeostasis and the metabolic syndrome.

Overall, the textbook is essential for medical students. It also can serve as a valuable resource for an upper level undergraduate course or a first year graduate course."
-Endocrine, December 2008

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